Dense fine speckled nuclear immunofluorescence: A mildly reassuring antinuclear antibody pattern meriting consideration

Abstract Introduction Antinuclear antibodies (ANAs) are regarded as a hallmark of connective tissue diseases (CTDs) and play key role in their diagnosis, but the value some particular management patients disease prognosis is controversial. The mechanism underlying production ANAs CTDs, other chronic inflammatory conditions even healthy people, not completely elucidated. Anti‐DFS70 connected with dense fine speckled autoantigen 70 kD, known lens epithelium‐derived growth factor p75, subgroup ANAs. Their presence coexistence clinical significance matter debate. Methods Based on literature data, authors focused current knowledge explaining anti‐DFS70 selected CTDs. Results However, data ambiguous does fully support validity assay for specific CTD diagnosis. Most researchers claim that only one usually exclude diagnosis CTD. Nevertheless, its an excluding has predictive due to more favorable course Such situations may also suggest enhanced risk development future. Conclusions Although studies needed this field, it seems reasonable ascertain routine practice.